Applying solitary-molecule optical and AFM imaging and force-spectroscopy techniques, we request to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions incorporate:
It absolutely was only within the nineteen nineties although, when nanotechnology experienced advanced to your level wherever single molecules may very well be manipulated, that the very first experimental products began to seem.
Round the identical time, the team of Paul McEuen, who was then dependent in the College of California, Berkeley, showed similar effects on ropes of bundled nanotubes. Dependant upon the wrapping angle, nanotubes can can be found in metallic or semiconducting variants, a prediction that we and Charles Lieber’s group at Harvard University independently verified employing scanning tunnelling spectroscopy experiments.
Non-equilibrium folding of person DNA molecules recaptured as much as 1000 occasions inside a strong state nanopore
2010, produced a brand new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by way of graphene nanopores; and understood hybrid nanopores by directed insertion of α-hemolysin into good-state nanopores
SMC complexes can move Bodily roadblocks bigger than their ring size, indicating a nontopological system for DNA loop extrusion
Duration Charge of personal carbon nanotubes by nanostructuring With all the scanning tunneling microscope
Atomic power microscopy demonstrates that vaccinia topoisomerase IB generates filaments on DNA inside a cooperative vogue
Knowing basic processes regulating the spatial and dynamic organisation of your DNA in live cells.
Dekker started his investigate on solitary carbon nanotubes in 1993 when he setup a completely new line of exploration to study electrical transportation by way of single natural and organic molecules amongst nanoelectrodes. In 1996 a breakthrough was realized with carbon nanotubes. This was realized within a collaboration Using the team of Nobel laureate Richard Smalley. STM and nanolithography strategies were accustomed to demonstrate that these nanotubes are quantum wires at The only-molecule level, with remarkable physical Houses.
Tests pseudotopological and nontopological designs for SMC-pushed DNA loop extrusion towards roadblock-traversal experiments
A lot of new phenomena were uncovered, and he and his research group recognized a number one place During this discipline of research. Dekker and his exploration group learned new physics of nanotubes and also explored the feasibility of molecular electronics. In 1998, they were being the initial to develop a transistor according to an individual nanotube molecule.
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It absolutely was a very intriguing time, all through which I acquired lots of guidance from Delft cees dekker College of Technologies, the place I had been a professor at some time, And that i began numerous collaborations with molecular biologists. That aided me master a great deal.’